Fishing at Cheyenne Bottoms is limited, for the most part, to carp and bullheads. Occasional catches of channel cat, crappie and bass are made after several continuous years of having water on the area.

Trapping is permitted on the wildlife area. A special permit is required. It is available at the area office free of charge. However, trapping is not permitted at any time in the refuge area nor during the waterfowl season.