The Fat Mucket Mussel is an obligate riverine species preferring slow moving current. They can tolerate a wide variety of substrates, but generally do not occur in areas of shifting sand. Fish hosts include crappies, common shiner, largemouth bass, tadpole madtom, and white sucker.
The current probable range of this mussel would include Grouse Creek and Walnut River in the Arkansas River basin; the Marais des Cygnes, Little Osage River, Marmaton River, Paint Creek, and Pottawatomie Creek in the Marais des Cygnes basin; and Caney River, Verdigris River, Spring River, and Neosho main stem within the Neosho basin.